Volodymyr V. Tkach
Chernivtsi National University, Ukraine
Title: Theoretical Investigation of the use of CoSn(OH)6 cubic nanoparticles for uric acid electrochemical detection in vivo and in vitro
Biography
Biography: Volodymyr V. Tkach
Abstract
Uric acid is the final product of the genetically determinated process of purine metabolism in the human and vertebrate animal organism. Its lack leads to the hyperuricemia and pathological states like Wilson and Fanconi disease. On the other hand, its excess leads to the Lesch-Nyhan syndrom. It makes actual the task of the seek of the efficient mechod of its concentration determination in organism. The redox activity of the uric acid let us apply the electroanalytical methods to it, especially those using the chemically modified electrodes, as the use of the modifiers accelerates the process and makes it more efficient. The cobalt(II)-tin(IV)-hydroxide is an interesting and modern electrode modifier, recently obtained in cubic nanopearticles. It is seen as an interesting candidate to catalyse the photo, photoelectro and electrochemical systems (including the sensing systems). Its use for the detection of the substances, which are oxidized in the similar conditions let us investigate theoretically the determination the possibility of the electrochemical detection of uric acid over an electrode, modified with this material in this work. The behavior of this system may be described by a tridimensial equation set, whose analysis shows that the electroanalytical system is driven efficiently, and may be diffusion- or reaction-controlled. The material may be used solely or in a composite with conducting polymers (polyaniline, polypyrrole, polycarbazole etc) and carbon materials (especially carbon paste, MWCNT and graphene). The oscillatory behavior is possible and may only be caused by DEL-capacitances change.