Satyendra Kumar Pandey
Thapar University, India
Title: Enantioselective, short and efficient approaches to the synthesis of drugs and biologically active compounds
Biography
Biography: Satyendra Kumar Pandey
Abstract
Asymmetric synthesis of bioactive molecules is at the forefront of synthetic organic chemistry due to its varied applications in drugs and pharmaceutical industries. Among an array of naturally occurring and biologically important compounds, the functionalized amino acids, 2-alkyl substituted tetrahydroquinolines, 2,5-disubstituted-3-oxygenated THF motifs and α-phenyl-β2-amino acid core unit are of great importance. They possess interesting pharmacological properties such as antiepileptic, antimalarial, potent olfactory activities and significant cytotoxicity against a variety of tumour cell lines including L1210 murine leukaemia and KB human epidermoid carcinoma cells. As part of our research on the asymmetric syntheses of drugs and bioactive compounds, we have recently synthesized medicinally important antiepileptic drug (R)-lacosamide, antimalarial agent (+)-angustureine, (+)-petromyroxol with potent olfactory activities, (+)-serinolamide A having affinity and selectivity for the CB1 receptor, and (S)-nakinadine B with signicant cytotoxicity against a variety of tumour cell lines including L1210 murine leukaemia and KB human epidermoid carcinoma cells.1