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15th World Conference on Pharmaceutical Chemistry, will be organized around the theme “New Tides in Pharma Industry”
Pharmaceutical Chemistry 2020 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Pharmaceutical Chemistry 2020
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Medicinal chemistry is the discovery, design and synthesis of potential new drugs. Pharmaceutical chemistry is the development of these into optimized drugs that can be sold as pharmaceuticals. The discovery and design of drugs requires an understanding of the biology of a disease to find an effective target for the drug, and will often involve computer-based in silico discovery and design of the drug structure. Research in Medicinal and Pharmaceutical Chemistry also includes the synthesis of the designed drugs, the optimization of their structures and action, and the development of methods for producing the drugs on a larger scale; these are challenging tasks which involve working in multidisciplinary teams with other members of the pharmacy research team as well as biologists, mathematicians and engineers.
- Track 1-1COVID-19
- Track 1-2Novel PARP inhibitors as promising targeted cancer therapies
- Track 1-3Chemistry of imaging probes
- Track 1-4Chemistry of bio-films and their inhibitors
- Track 1-5Discovering novel antibiotics
Drug discovery is a process which is intended to identify a small synthetic molecule or a large biomolecule for comprehensive evaluation as a potential drug candidate. Broadly, the modern drug discovery process includes identification of disease to be treated and its unmet medical need, selection of a druggable molecular target and its validation, in vitro assay development followed by high throughput screening of compound libraries against the target to identify hits, and hit optimization to generate lead compounds that exhibit adequate potency and selectivity towards the biological target in vitro and which demonstrate efficacy in animal models of disease. Subsequently, the lead compounds are further optimized to improve their efficacy and pharmacokinetics before they advance towards drug development.
Drug development process can be segregated into preclinical and clinical development stages. In preclinical development, toxicological and safety pharmacology studies of the candidate are conducted in order to establish the maximum safe concentrations in animals and determine the adverse effect potential of the drug-in-development. Additionally, studies are conducted to finalize cost-effective processes required for manufacturing the candidate drug as well as deciding on its best formulation. If the candidate exhibits sufficient efficacy and safety in preclinical evaluation, permission is sought from drug regulatory agencies to initiate its clinical development wherein the safety and efficacy of the drug candidate is assessed in pilot and pivotal studies.
- Track 2-1Computational approaches in drug discovery and precision medicine
- Track 2-2Phosphonate chemistry in drug design and development
- Track 2-3In silico methods for drug design and discovery
- Track 2-4Neglected Diseases: Chagas Disease, Human African Trypanosomiasis, and Leishmaniasis
- Track 2-5Anti-Tubercular drugs
- Track 2-6Computational drug discovery for targeting of protein-protein interfaces
- Track 2-7Multi-target-directed ligands (MTDL) in drug discovery: from design to pharmacological evaluation
Design of a novel drug is one of the biggest challenges faced by the pharmaceutical industry. The use of computers accelerates the process of drug design which is a time intensive process, and also reduces the cost of whole process. Computational methods are used in various forms of drug discovery like QSAR, virtual screening and structure-based drug designing methods. Among these, structure based drug design is gaining importance due to rapid growth in structural data (available in RCSB & Nucleic acid Data Bank). This structural data can be used in molecular modeling to design lead molecules based on the structural features of the active site.
- Track 3-1Novel spiro compounds
- Track 3-2Rational drug discovery
- Track 3-3Computer-aided drug design
- Track 3-4Structure & ligand-based
- Track 3-5Virtual drug design
Clinical research is the study of health and illness in people. It is the way we learn how to prevent, diagnose and treat illness. Clinical research describes many different elements of scientific investigation. Simply put, it involves human participants and helps translate basic research (done in labs) into new treatments and information to benefit patients. Clinical trials as well as research in epidemiology, physiology and pathophysiology, health services, education, outcomes and mental health can all fall under the clinical research umbrella.
- Track 4-1Epidemics and pandemics
- Track 4-2Stem cells research
- Track 4-3Alzheimer disease
- Track 4-4HIV/AIDS
- Track 4-5Cancer treatment and research
- Track 4-6Palliative treatment
- Track 4-7Artificial tissues and organs
- Track 4-8Biomechanics in medicine
- Track 4-9Alternative medicine
- Track 4-10Genetic engineering and cloning
- Track 4-11Ethical aspects of medical research on humans and animals
- Track 4-12Virus infections and their treatment
- Track 4-13Antibiotics and their role in the treatment of diseases
- Track 4-14Treatment of pregnant women and their differences
- Track 4-15Child health care and its differences from the adult ones
- Track 4-16Sleep disorders
A review of the use of natural products as starting points in the search for new pharmaceuticals, covering the broad areas of Drugs affecting the central nervous system, Neuromuscular blocking drugs, Anticancer drugs, Marine sources, Antibiotics, Cardiovascular drugs, Antiasthma drugs, Anti-diabetic drugs and Antiparasitic drugs. The review covers more than 100 years of development, from “old” drugs, such as morphine and quinine, to very recent discoveries, such as conotoxin and galantamine, and includes a discussion of the attributes of natural products as leads in the drug discovery process. Between 1990 and 2000, a total of 41 drugs derived from natural products were launched on the market by major pharmaceutical companies. In the chosen examples, the process of drug development is traced from the discovery of the activity of the natural compound, through chemical modification and biological evaluation, to either success or failure as a clinical product, highlighting the very different pathways to innovation that occur in each product.
- Track 5-1Primary & secondary metabolites
- Track 5-2Isolation, purification and synthesis
- Track 5-3Natural products from marine macro & microorganisms
- Track 5-4Nanotechnology in traditional medicines and natural products
- Track 5-5Natural products as anticancer drug leads
- Track 5-6CNS, Neuromuscular, Cardiovascular, Asthama, Diabetic, Parasitic, Antibiotic
Pharmaceutical biotechnology is a relatively new and growing field in which the principles of biotechnology are applied to the development of drugs. A majority of therapeutic drugs in the current market are bioformulations, such as antibodies, nucleic acid products and vaccines. Such bioformulations are developed through several stages that include: understanding the principles underlying health and disease; the fundamental molecular mechanisms governing the function of related biomolecules; synthesis and purification of the molecules; determining the product shelf life, stability, toxicity and immunogenicity; drug delivery systems; patenting; and clinical trials.
- Track 6-1DNA/protein engineering and processing
- Track 6-2Synthetic biotechnology
- Track 6-3Genomics, proteomics, metabolomics and systems biology
- Track 6-4Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
- Track 6-5Drug delivery and targeting
- Track 6-6Nano biotechnology
- Track 6-7Molecular pharmaceutics and molecular pharmacology
- Track 6-8Analytical biotechnology (bio sensing, advanced technology for detection of bioanalytes)
- Track 6-9Pharmacokinetics and pharmacodynamics
- Track 6-10Applied microbiology
- Track 6-11Bioinformatics (computational bio pharmaceutics and modeling)
- Track 6-12Environmental biotechnology
- Track 6-13Regenerative medicine (stem cells, tissue engineering and biomaterials)
- Track 6-14Translational immunology (cell therapies, antibody engineering, xenotransplantation)
- Track 6-15Industrial bioprocesses for drug production and development
- Track 6-16Biosafety & biotech ethics
Green chemistry expresses an area of research developing from scientific discoveries about pollution awareness and it utilizes a set of principles that reduces or eliminates the use or generation of hazardous substances in all steps of particular synthesis or process. Chemists and medicinal scientists can greatly reduce the risk to human health and the environment by following all the valuable principles of green chemistry. The most simple and direct way to apply green chemistry in pharmaceuticals is to utilize eco-friendly, non-hazardous, reproducible and efficient solvents and catalysts in synthesis of drug molecules, drug intermediates and in researches involving synthetic chemistry. Microwave synthesis is also an important tool of green chemistry by being an energy efficient process.
- Track 7-1Organic synthesis
- Track 7-2Green chemistry meets white biotechnology
- Track 7-3Solvent use and waste issues
- Track 7-4Waste minimization and solvent recovery
- Track 7-5Continuous processing in the pharmaceutical industry
- Track 7-6Green technologies in the generic pharma
Computational chemistry within the pharmaceutical industry has grown into a field that proactively contributes too many aspects of drug design, including target selection and lead identification and optimization. While methodological advancements have been key to this development, organizational developments have been crucial to our success as well. In particular, the interaction between computational and medicinal chemistry and the integration of computational chemistry into the entire drug discovery process have been invaluable.
- Track 8-1Proteomics
- Track 8-2Glycobiology
- Track 8-3Combinatorial chemistry
- Track 8-4Molecular sensing
- Track 8-5Chemical synthesis of peptides
Organic chemistry is one of the branches of chemistry that majorly deals with the study of different molecular structures, compositions, properties and synthesis of different compounds. These compounds under study majorly contain hydrocarbons, carbon and their derivatives. The combination of these compounds in an effort to come up with different medicinal ingredients can be put under synthetic organic chemistry procedures.
The science of pharmaceuticals is a field with disciplines that work together. This discipline usually works together through synthetic organic chemistry to bring out pharmaceutical drug compounds with intense effects. Synthetic organic chemistry and pharmaceutical chemistry are both involved in the manufacture of pharmaceutical drugs.
- Track 9-1Chemical bonding and molecular structure
- Track 9-2Stereochemistry, conformation, and stereoselectivity
- Track 9-3Polar addition and elimination reactions
- Track 9-4Ligands and metal complexes
- Track 9-5Organometallic chemistry and catalysis
Inorganic chemistry is the study of all the elements and their compounds except carbon and its compounds. Inorganic chemistry describes the characteristics of substances such as non-living matter and minerals which are found in the earth except the class of organic compounds. Branches of inorganic chemistry include coordination chemistry, bioinorganic chemistry, organometallic compounds and synthetic inorganic chemistry. The distinction between the organic and inorganic are not absolute, and there is much overlap, especially in the organometallic chemistry, which has applications in every aspect of the pharmacy, chemical industry–including catalysis in drug synthesis, pigments, surfactants and agriculture. In short, Inorganic chemistry is the branch of chemistry that deals with inorganic compounds. In other words, it is the chemistry of compounds that do not contain hydrocarbon radicals.
New advances in synthetic methodologies that allow rapid access to a wide variety of functionalized heterocyclic compounds are of critical importance to the medicinal chemist as it provides the ability to expand the available drug-like chemical space and drive more efficient delivery of drug discovery programs. Furthermore, the development of robust synthetic routes that can readily generate bulk quantities of a desired compound help to accelerate the drug development process. While established synthetic methodologies are commonly utilized during the course of a drug discovery program, the development of innovative heterocyclic syntheses that allow for different bond forming strategies are having a significant impact in the pharmaceutical industry. This review will focus on recent applications of new methodologies in C-H activation, photoredox chemistry, borrowing hydrogen catalysis, multicomponent reactions, regio- and stereoselective syntheses, as well as other new, innovative general syntheses for the formation and functionalization of heterocycles that have helped drive project delivery.
- Track 11-1Five-membered heterocycles with one heteroatom
- Track 11-2Five-membered heterocycles with two and more than two heteroatoms
- Track 11-3Benzo-fused five-membered heterocycles with one heteroatom
- Track 11-4Meso-ionic heterocycles
Pharmaceutical formulation is the process of combining various chemical substances with the active drug to form a final medicinal product, which is called a drug mixture or drug formulation. A drug formulation can be given to the patient in various forms like solid, semisolid or liquid. The type of the formulation given depends upon the patient’s age, sex, and health condition and is specific for particular routes of administration.
- Track 12-1Hard capsules in modern drug delivery
- Track 12-2Soft capsules
- Track 12-3Tablet formulation
- Track 12-4Suspension quality by design
- Track 12-5Film coating of tablets
- Track 12-6Oral controlled release technology and development strategy
- Track 12-7Less common dosage forms
Pharmaceutical analysis is a branch of practical chemistry that involves a series of process for identification, determination, quantification and purification of a substance, separation of the components of a solution or mixture, or determination of structure of chemical compounds. The substance may be a single compound or a mixture of compounds and it may be in any of the dosage form. The substance used as pharmaceuticals are animals, plants, microorganisms, minerals and various synthetic products.
- Track 13-1Control of the quality of analytical methods
- Track 13-2Physical and chemical properties of drug molecules
- Track 13-3Titrimetic and chemical analysis
- Track 13-4Extraction methods
- Track 13-5Separation techniques
- Track 13-6Methods used in the quality control
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future. Biomedical engineers have contributed substantially to our understanding of the physiological barriers to efficient drug delivery, such as transport in the circulatory system and drug movement through cells and tissues; they have also contributed to the development several new modes of drug delivery that have entered clinical practice.
- Track 14-1Polymeric drug delivery technique
- Track 14-2Drug delivery using nanotechnology
- Track 14-3Transdermal drug delivery system
- Track 14-4Novel drug delivery system
- Track 14-5Rational drug design techniques
- Track 14-6Bio-adhesive drug delivery system
Pharmacology is the study of how a drug affects a biological system and how the body responds to the drug. The discipline encompasses the sources, chemical properties, biological effects and therapeutic uses of drugs. These effects can be therapeutic or toxic, depending on many factors. Pharmacologists are often interested in therapeutics, which focuses on the effects of drugs and other chemical agents that minimize disease, or toxicology, which involves the study of adverse, or toxic, effects of drugs and other chemical agents. Toxicology can refer to both drugs used in the treatment of disease and with chemicals that may be present in household, environmental, or industrial hazards.
- Track 15-1Cellular and molecular pharmacology
- Track 15-2Pharmacology education
- Track 15-3Pharmacogenomics & pharmacogenetics
- Track 15-4Drug metabolism and disposition
- Track 15-5Drug discovery and development
- Track 15-6Translational pharmacology
- Track 15-7Rare diseases and orphan drugs, and drug repositioning
- Track 15-8Redox regulators and biological gases in pathophysiology
- Track 15-9Pregnancy related pharmacology and perinatal therapeutics
- Track 15-10Renal pathophysiology
- Track 15-11Immunology (clinical and basic)
- Track 15-12Gastrointestinal and urogenital
- Track 15-13Central nervous system pharmacology
- Track 15-14Cardiovascular pharmacology
- Track 15-15Cancer pharmacology
- Track 15-16Receptor pharmacology
Toxicology is a field of science that helps us understand the harmful effects that chemicals, substances, or situations, can have on people, animals, and the environment. Some refer to toxicology as the “Science of Safety” because as a field it has evolved from a science focused on studying poisons and adverse effects of chemical exposures, to a science devoted to studying safety. Toxicology uses the power of science to predict what, and how chemicals may cause harm and then shares that information to protect public health.
- Track 16-1Clinical toxicology
- Track 16-2Food and chemical toxicology
- Track 16-3Environmental toxicology
- Track 16-4Ecotoxicology
- Track 16-5Occupational toxicology
- Track 16-6Regulatory toxicology