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15th World Conference on Pharmaceutical Chemistry, will be organized around the theme “New Tides in Pharma Industry”
Pharmaceutical Chemistry 2020 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Pharmaceutical Chemistry 2020
Submit your abstract to any of the mentioned tracks.
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Pharmaceutical chemistry is a branch at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various biological specialties, where they are involved with drug design, chemical synthesis and development for market, or bio-active molecules (drugs). In particular, Pharmaceutical chemistry in its most common guide focusing on small organic molecules/entities encompasses synthetic organic chemistry and aspects of natural products chemistry and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the drug discovery and development of new various therapeutic agents. Practically speaking, it involves chemical aspects of identification, and later systematic, thorough synthetic alteration of new chemical entities to make them appropriate for therapeutic use. It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for purpose of medicinal products.
- Track 1-1Advanced organic synthesis techniques
- Track 1-2Analytical method development
- Track 1-3Screening of drug candidates and lead molecules
- Track 1-4Metabolic stability studies
- Track 1-5Molecular modelling based drug design system
Computational chemists' daily work influences our understanding of the way the world works, helps manufacturers design more productive and efficient processes, characterizes new compounds and materials, and helps other researchers extract useful knowledge from mountains of data. Computational chemistry is also used to study the fundamental properties of atoms, molecules, and chemical reactions, using quantum mechanics and thermodynamics.
Chemical Biology research uses the tools of chemistry and synthesis to understand biology and disease pathways at the molecular level. Advanced biological chemistry interests include diverse topics such as nucleic acids, DNA repair, bioconjugate chemistry, electron transport, peptides and peptidomimetics, glycoscience, biochemical energy, vitamins, cofactors and coenzymes, biomolecular structure and function, drug activity, imaging, and biological catalysis. Biophysical Chemistry represents the union of chemistry, physics, and biology using a variety of experimental and theoretical approaches to understand the structure and function of biological systems.
- Track 2-1Proteomics
- Track 2-2Glycobiology
- Track 2-3Combinatorial chemistry
- Track 2-4Molecular sensing
- Track 2-5Chemical synthesis of peptides
Typically, researchers discover new drugs through: New insights into a disease process that allow researchers to design a product to stop or reverse the effects of the disease. Many tests of molecular compounds to find possible beneficial effects against any of a large number of diseases. Existing treatments that have unanticipated effects. New technologies, such as those that provide new ways to target medical products to specific sites within the body or to manipulate genetic material.
At this stage in the process, thousands of compounds may be R & D potential candidates for development as a medical treatment. After early testing, however, only a small number of compounds look promising and call for further study.
Once researchers identify a promising compound for development, they conduct experiments to gather information on:
How it is absorbed, distributed, metabolized, and excreted
Its potential benefits and mechanisms of action
The best dosage
The best way to give the drug (such as by mouth or injection)
Side effects (often referred to as toxicity)
How it affects different groups of people (such as by gender, race, or ethnicity) differently
How it interacts with other drugs and treatments
Its effectiveness as compared with similar drugs
- Track 3-1Sequencing
- Track 3-2High throughput screening
- Track 3-3Biological targets
- Track 3-4Screening and design
- Track 3-5New chemical entity development
- Track 3-6Novel initiatives to boost development
The fundamental problem in computational drug design is accurately estimating ligand-receptor binding affinity. Historically, this shortcoming combined with the complexity, resources, and time requirements has hampered the utility of structure-based drug design.
However, Moore's Law coupled with recent advances in GPU driven computing have made it possible to achieve accurate results in reasonable time frames.
These calculations are performed alchemically using molecular dynamics to adequately sample a suitable thermodynamic path and intermediate states. The measured energies during alchemical transformation are then used to computationally estimate ligand-receptor binding affinity by a number of published techniques - including: Thermodynamic integration
Weighted Histogram Analysis Method
Bennett Acceptance Ratio
Linear Interaction Energy
- Track 4-1Drug targets
- Track 4-2Rational drug discovery
- Track 4-3Computer-aided drug design
- Track 4-4Ligand-based
- Track 4-5Structure-based
Natural products are naturally occurring substances that are used to restore or maintain good health. They are often made from plants, animals, microorganisms and marine sources. They come in a wide variety of forms like tablets, capsules, tinctures, solutions, creams, ointments and drops. Natural products are used and marketed for a number of health reasons, like the prevention or treatment of an illness or condition, the reduction of health risks, or the maintenance of good health. They must be safe to be used as over-the-counter products. Products needing a prescription are regulated as drugs. Natural Products are used for various purposes like skin and hair care, dietary supplement, baby care, organic and natural herbal products.
- Track 5-1Primary metabolites
- Track 5-2Secondary metabolites
- Track 5-3Biosynthesis
- Track 5-4Isolation and purification
- Track 5-5Synthesis
The last few years have been a positive period overall for both the pharmaceutical and biotechnology industries. Most importantly, there has been a renaissance with regard to the increase in the number of new drugs approved and under development for the two segments of the business.
Many of these innovations are driven by new research methods and the growth of new therapeutic options, such as immune-related oncology drugs, personalized medicine, stem cells, and biologics. We are also witnessing the development of a greater number of drugs that cure diseases rather than just extend life.
The valuations of pharma and biotech companies in the public and M&A markets soared up until August/September of this year in part because of these positive developments. More recently, there has been a setback in public valuations due to the negative publicity about drug pricing.
- Track 6-1Protein stability and characterization
- Track 6-2Immunogenicity of therapeutic proteins
- Track 6-3Monoclonal antibodies in cancer
- Track 6-4Monoclonal antibodies in solid organ transplantation
- Track 6-5Stem cells in tissue engineering
- Track 6-6Chemical stimulation (growth factors and hormones)
Preventing environment pollution is a crucial issue within the current world than cleansing up the atmosphere. By tradition, chemists have designed product that ar effective and economical. They need not thought of the waste generated throughout process of the new chemicals and product and its toxicity. Inventing any new product that are of concern to North American country or ecosystems ultimately goes into the environment at the top of the lifetime of these substances, resulting in accumulation, degradation and toxicity. Hence, it's invariably higher to settle on the process protocols that generate minimum Industrial waste and finished product with few chemicals usage and synthesis steps. Our science builds on nice achievements by chemicals and chemists. It’s been quite a hundred and fifty years that we've got been finding the way to create new molecules. and therefore the modern chemistry with its inventions has improved lots our lives providing an out of this world array of product in each field (consumer product, cloths and electronics) and in the main save lives on this earth with new medicines.
In nature, green chemistry is cleaner, cheaper and smarter and it prevents pollution at molecular level. By definition, it's a philosophy of chemical analysis and engineering that encourages the design of products and processes that minimize the employment and generation of unsafe substances. In ancient chemistry, we have a tendency to use lots of abundance of beginning material to urge the ultimate product and discard most of it as waste. The theme of green chemistry is to maximise the incorporation of the beginning materials or reagents into the ultimate product and conjointly to develop a way that synthesizes a required product by generating basic building blocks (at molecular level), instead of by breaking down a bigger starting material. for creating most of the product (consumer product, cloths, cosmetics and electronics) and chemicals, varied chemicals ar mixed along in larger quantities that ar probably toxic liquids and solvents to urge a final product. and therefore the prescribed drugs also are created within the same fashion to urge a finished chemical product. Hence, most of the waste generated within the chemical industries is solvent connected (80-85%). Now, the industry is historically viewed a lot of as a cause than an answer to pollution, although chemistry offers distinctive solutions within the space of waste prevention.
- Track 7-1Organic synthesis
- Track 7-2Green chemistry meets white biotechnology
- Track 7-3Solvent use and waste issues
- Track 7-4Waste minimization and solvent recovery
- Track 7-5Continuous processing in the pharmaceutical industry
- Track 7-6Green technologies in the generic pharma
Organic reactions square measure chemical reactions involving organic compounds. The fundamental chemistry reaction sorts square measure addition reactions, elimination reactions, substitution reactions, pericyclic reactions, arranging reactions, chemistry reactions and reaction reactions. In organic synthesis, organic reactions square measure employed in the development of recent organic molecules. The assembly of the many synthetic chemicals like medicine, plastics, food additives, and materials depend upon organic reactions. There is no limit to the quantity of doable organic reactions and mechanisms. However, sure general patterns square measure determined that may be accustomed describe several common or helpful reactions. Every reaction features a stepwise reaction mechanism that explains however it happens, though this elaborate description of steps isn't invariably clear from a listing of reactants alone. Synthetic organic reactions will be organized into many basic sorts. Some reactions match into over one class. For instance, some substitution reactions follow an addition-elimination pathway.
In general the stepwise progression of reaction mechanisms will be diagrammatical victimization arrow pushing techniques during which incurved arrows square measure accustomed track the movement of electrons as starting materials transition to intermediates and products.
- Track 8-1Chemical bonding and molecular structure
- Track 8-2Stereochemistry, conformation, and stereoselectivity
- Track 8-3Polar addition and elimination reactions
- Track 8-4Ligands and metal complexes
- Track 8-5Organometallic chemistry and catalysis
Heterocyclic compound or ring structure may be a cyclic compound that has atoms of a minimum of two completely different components as members of its ring(s). Heterocyclic chemistry is that the branch of chemistry addressing the synthesis, properties and applications of those heterocycles. In distinction, the rings of isocyclic compounds consist entirely of atoms of constant part.
Although heterocyclic compounds could also be inorganic, most contain a minimum of one carbon. Whereas atoms that square measure neither carbon nor hydrogen are normally referred to in organic chemistry as heteroatoms, this can be typically compared to the all-carbon backbone. However this doesn't stop a compound like borazine (which has no carbon atoms) from being tagged "heterocyclic". IUPAC recommends the Hantzsch-Widman language for naming heterocyclic compounds.
- Track 9-1Five-membered heterocycles with one heteroatom
- Track 9-2Five-membered heterocycles with two and more than two heteroatoms
- Track 9-3Benzo-fused five-membered heterocycles with one heteroatom
- Track 9-4Meso-ionic heterocycles
Formulation is the process where different chemical substances including the drug product which are combined to produce a medicinal product. There are various anatomical routes which are thought them as medical drugs that can be administered directly into the human body. The selection process of the route depends upon three factors which are: the effect desired type of disease & finally the type of product. Oral route is the oldest route which has been used for conventional & the novel drug delivery administration. Parenteral route, these are the routes which include intramuscular, intravenous, and intra-arterial and the subcutaneous route. Transdermal route is the medical treatment that will apply on surfaces of the body such as skin/mucous membrane. Inhalation route, is the type of medical treatment application route where the medical treatment will directly reach the lungs, through this way this route is considered as route of choice to avoid systemic effect and increase the bioavailability of the drug in the system.
- Track 10-1Hard capsules in modern drug delivery
- Track 10-2Soft capsules
- Track 10-3Tablet formulation
- Track 10-4Suspension quality by design
- Track 10-5Film coating of tablets
- Track 10-6Oral controlled release technology and development strategy
- Track 10-7Less common dosage forms
Analytical methods must be validated to provide reliable data for regulatory submissions. These methods are essential for a number of purposes, including testing for QC release, testing of stability samples, testing of reference materials and to provide data to support specifications. It provides a comprehensive coverage of method development and validation requirements to progress a pharmaceutical compound, at each stage of product development.
- Track 11-1Control of the quality of analytical methods
- Track 11-2Physical and chemical properties of drug molecules
- Track 11-3Titrimetic and chemical analysis
- Track 11-4Extraction methods
- Track 11-5Separation techniques
- Track 11-6Methods used in the quality control
Pharmacology is the study of how substances interact with living organisms to produce a change in function. It deals with the research, discovery, and characterization of chemicals which show biological effects and the illumination of cellular and organism function in relation to these chemicals. If substances have medicinal properties, they are considered pharmaceuticals. The Pharmacology encompasses mechanisms of drug action, drug composition and properties, interactions, toxicology, therapies, medical applications, and antipathogenic capabilities.
These are research studies that test how well new medical approaches work in people. Each study answers scientific questions and tries to find better ways to prevent, screen for, diagnose, or treat a disease. Clinical trials may also compare a new treatment to a treatment that is already available.
- Track 12-1Mechanisms of drug action
- Track 12-2Pharmacokinetics and pharmacodynamics
- Track 12-3ADME
- Track 12-4Therapeutic drug monitoring
- Track 12-5Adverse drug reactions
- Track 12-6Drug interactions
- Track 12-7Pharmacogenetics
Drug delivery systems control the rate at which a drug is released and the location in the body where it is released. Some systems can control both.
Clinicians historically have attempted to direct their interventions to areas of disease or areas at risk for disease. Depending on the medication, the way it is delivered, and how our bodies respond, side effects sometimes occur. These side effects can vary greatly from person to person in type and severity. For example, an oral drug for seasonal allergies may cause unwanted drowsiness or an upset stomach.
Administering drugs locally rather than systemically (affecting the whole body) is a common way to decrease side effects and drug toxicity while maximizing a treatment’s impact. A topical (used on the skin) antibacterial ointment for a localized infection or a cortisone injection of a painful joint can avoid some of the systemic side effects of these medications. There are other ways to achieve targeted drug delivery, but some medications can only be given systemically.
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents.
- Track 13-1Polymeric drug delivery technique
- Track 13-2Drug delivery using nanotechnology
- Track 13-3Transdermal drug delivery system
- Track 13-4Novel drug delivery system
- Track 13-5Rational drug design techniques
- Track 13-6Bio-adhesive drug delivery system