Raffaella Mancuso
University of Calabria, Italy
Title: From simple chemical building blocks to biological active molecules
Biography
Biography: Raffaella Mancuso
Abstract
The development of new synthetic strategies for the synthesis of biologically active products characterized by a reduced number of steps and high efficiency is an important goal in modern pharmaceutical chemistry. In this lecture, some particularly interesting examples of the synthesis of bioactive molecules realized in a multicomponent fashion starting from very simple and largely available building blocks, under mild and sustainanable conditions, will be illustrated, with special emphasis on catalytic processes. In particular, the catalytic syntheses of new heterocycles with antitumor activity (z-lactame, cyclic urea, spiro-isoindolinisoxazolidine and furofuranone derivatives), antibacterial activity (benzofurofuranone derivatives), and herbicidal activity (benzofuran, coumarin, and isobenzofuranimine derivatives) will be discussed.