Naofumi Hashimoto
Setsunan University, Japan
Title: Preparation of nanocrystal formulation to improve oral absorption of mebendazole
Biography
Biography: Naofumi Hashimoto
Abstract
Nano-sizing by wet beads milling is a method to improve the solubility of poorly water soluble compounds. Mebendazole (MBZ) is a well-known anthelmintic drug in wide clinical use. Recently, there were some reports that MBZ had the anticancer effect in preclinical study. However, the bioavailability of MBZ is low (<10%) due to poor solubility in water (ca. 0.5 µg/mL). The present investigation aimed to develop the nanocrystal formulations (about D50=120 nm) of MBZ with improved dissolution behavior and thereby enhanced oral absorption.
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