Rongshi Li
University of Nebraska Medical Center, USA
Title: Fragment-based, Structure-guided and Natural Product-derived Small Molecules as Antibiotic and Anticancer Agents
Biography
Biography: Rongshi Li
Abstract
Natural products, their derivatives, metabolites, and mimics account for approximately half of the New Chemical Entities for drug discovery. To date, natural products have provided the largest supply of successful drug leads [Newman and Cragg, J. Nat. Prod. 2012, 75, 311]. Marine natural products have contributed to eight drugs or cosmeceuticals that were approved by the US Food and Drug Administration and European Medicines Agency [Li, R. Med. Res. Rev. 2016, 36, 3 and 169]. Fragment-based and structure-guided drug design and discovery are powerful tools. Coupling these tools with natural product-derived fragments and scaffolds will expedite successful outcomes in drug discovery and development. This presentation will discuss the design, synthesis, and Structure- Activity-Relationships of natural product fragments and their derivatives for their development as potential antibiotic and anti-cancer agents.
Acknowledgment: This work is partially supported by R01CA173056 (NIH/NCI, PI: Li), Nebraska Research Initiative (NRI) grant (State of Nebraska, PI: Li), Pediatric Cancer Research Program LB905 (State of Nebraska, PI: Coulter) and startup funds (University of Nebraska Medical Center,
PI: Li).