Imene SEHOUT
University of Constantine, Algeria
Title: New Green Synthesis of 1.8-Dioxodecahydroacridine Derivatives and Polyhydroquinolines, via Two Natural Catalysts in a Solvent-Free Medium
Biography
Biography: Imene SEHOUT
Abstract
Requirements of modern chemistry, including the development of new synthesis with new secure, economic and environmentally protocols guide us to the field of green chemistry [1]. The development of solvent-free organic synthetic methods has become an important research area, aiming to save energy and to prevent hazardous solvent waste and toxicity in chemical processes. On the other hand, the catalyst is the most important factor in organic synthesis for its important role in a reaction by its presence or by its intervention. Green chemistry has allowed the emergence of new horizons in the field of catalysis; it is now the ninth principle of green chemistry. Several green methods were applied as microwave [2], ultrasound [3], ionic liquids [4], nanoparticles [5]. On our part we have contributed to this effect by the development of two new natural catalysts, inexpensive, non-toxic and very available, which are ascorbic acid and acetyl salicylic acid. We applied our two new natural catalysts in the Hantzsch reaction (Figure:1), which is a multicomponent reaction, it is considered as a green reaction, by the fact they generate in record time and with good yields molecular structures with great complexity. The achieved results are remarkable, we could synthesize a range of 1.8-dioxodecahydroacridine derivatives (6), and polyhydroquinolines (7) with yields ranging between (47-99) % in the time range from (1.5-6) hours, we also enriched the bibliography molecules by synthesis of authentic molecules.