Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Adriano Mollica

Adriano Mollica

G. D’ annunzio” of Chieti-Pescara, Italy

Title: Newly potent opioid peptides with analgesic activity containing a xylene bridge

Biography

Biography: Adriano Mollica

Abstract

Novel cyclic analogues of enkephalin containing xylene bridge regioisomers  (7a-c) have been synthesized and fully characterized as mixed m,d opioid receptors agonists.a,b The in vitro activity has been investigated showing a good affinity of 7a-c for both of them. In vivo biological assays revealed that 7b is the most potent cyclic analogue with the ability to maintain high level of analgesia after 60 and 90 minutes following i.c.v. and i.t. administrations respectively in Tail Flick test and long lasting analgesia after subcutaneous administration.