Evgeny Pliss
P.G. Demidov Yaroslavl State University, Russian Federation
Title: Oxidative stress simulation by radical-chain oxidation of vinyl compounds
Biography
Biography: Evgeny Pliss
Abstract
A combination of microvolumetry, the rotating sector method, ESR, 1H-NMR, and IR allowed to establish a detailed mechanism of liquid-phase oxidation of vinyl compounds. A distinctive feature of the mechanism is the fact that the oxidation chain is carried out by a low-molecular hydroperoxide radical. Kinetic, correlation, and quantum-chemical analysis of these processes allows modeling the processes leading to oxidative stress in living organisms. The report analyses the routes of various chemical reactions that reduce the negative impact of oxidative stress. The study is proposes the use of a stable nitroxyl radicals of piperidine, pyrroline and imidazoline series as one of the effective components, leading to a positive effect.
The research is supported by RSF grant No. 14-23-00018.