Nurmeilis
Syarif Hidayatullah State Islamic University. Indonesia
Title: Pharmacological Evaluation of Sedative and Hypnotic Activity of Ethyl p-methoxycinnamate and N-hydroxyethyl-p-cinnamamide
Biography
Biography: Nurmeilis
Abstract
Ethyl p-methoxycinnammate (1) was found as a major isolated compound from the rhizome of Kaempferia galanga. This compound has been reported to have various biological activities such as mosquito repellent and larvicidal, anti-tuberculosis, sedative, anticancer, analgesic and anti-inflammatory and hypo pigmentary. In this research, we have evaluated the sedative and hypnotic activity of 1 and its amide derivative, N-hydroxyethyl-p-cinnamamide (2). The method was carried out by evaluating significant sedative and hypnotic effect of 1 and 2 at the doses of 100, 200 and 400 mg/kg (by oral route), compared to reference substance diazepam in hole board and thiopental-induced sleeping time methods. In conclusion, compound 1 has 2 has a potential sedative and hypnotic activity, whereas compound 1 was significantly different to the negative control (p≤0,05).