Gisela Brändén,
University of Gothenburg, Sweden
Title: Structural studies of the novel antibacterial target MraY and its interaction with the natural inhibitor compound tunicamycin
Biography
Biography: Gisela Brändén,
Abstract
The rapid increase of antibiotic resistance has created an urgent need to develop novel antibacterial drugs. I will describe the crystal structure of the promising bacterial target phospho-N-acetylmuramoyl–pentapeptide translocase (MraY) in complex with the nucleoside antibiotic tunicamycin. The structure reveals the mode of action of several related natural-product antibiotics and also gives an indication on the binding mode of the MraY UDP–MurNAc–pentapeptide and undecaprenyl-phosphate substrates.
(Hakulinen et al. Nature Chemical Biology, 13:265-267, 2017)