Biography
Biography: Mohamed Elagawany
Abstract
Macrocyclic peptides now draw considerable attention as potential therapeutics due to their roles as mediators of key biological functions together with low toxicity and high specificity. Wellknown examples of cyclic peptide drugs include the natural antibiotic vancomycin, hormone oxytocine, neuropeptide vasopressin and antibiotics cyclosporine and tyrocidine A.1-3 A facile and economic strategy was developed to synthesize macrocyclic peptidomimetic
(compounds A and B) and naturally occurring Rolloamide A and B in a good yield. The substances showed strikingly high activity against Candida albicans and three Gramnegative bacterial strains. An excellent selectivity with respect to human cells was found, which implies low human toxicity.