Fatemeh Majidi Arlan
University of Urmia, Iran
Title: Synthesis of new series of pyrazolo[3,4-b][1,6]naphthyridine in presence of nano-Al2O3
Biography
Biography: Fatemeh Majidi Arlan
Abstract
Pyrazolonaphthyridine is a fused polycyclic heterocycles with four nitrogen-atoms, the pyrazolonaphthyridine derivatives have received much attention in recent years due to their wide biological and pharmacological activities such as potent phosphodiesterase 10A inhibitors [1], selective histamine 4 receptor antagonists [2] bombesin receptor subtype-3 agonists [3] and protein kinase inhibitors [4]. Herein, we report the one-pot threecomponent synthesis of new series of pyrazolo[3,4-b][1,6]naphthyridine in the presence of different catalysts such as L-alanin, p-TSA and nano Al2O3. Ease of purification of products, isolation of catalysts, using water/ ethanol as a green solvent, high yields and shorter reaction times in presence of nanocatalyst in comparison with other catalysts are the advantages of this procedure.