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Gabriela Pricope


Gabriela Pricope

Centre of Advanced Research in Bionanoconjugates and Biopolymers, Romania

Biography

Supramolecular hydrogels have been extensively studied for their biomedical and pharmaceutical applications. Proprieties such as high water content and the soft consistency, similar to the consistency of natural tissue, contributes to their biocompatibility. Furthermore, the ability of different sized molecules to diffuse into (drug loading) and out of hydrogels (drug release) make these materials perfect candidates for drug delivery systems. In this report, hydrogels based on the formation of G-quartet were proposed and studied for the incorporating and releasing of the active compounds. An in situ method for drug loading was selected, thus the hydrogel network formulation and the drug encapsulation were accomplished simultaneously. The release of the encapsulated compounds was determined by diffusion in buffer solutions at physiological and acidic pH values. Drug-release measurements were performed using UV-Vis spectroscopy, fluorometry and circular dichroism spectroscopy. Presented work also shows the influence of structural components upon drug loading/release properties of the newly prepared hydrogels.

Abstract

Abstract : Supramolecular G-quartet architectured hydrogels as drug delivery systems